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Spectroscopic study of in situ‐formed metallocomplexes of proton pump inhibitors in water
Author(s) -
Abramenko Nikita,
Kejík Zdeněk,
Kaplánek Robert,
Tatar Ameneh,
Brogyányi Tereza,
Pajková Martina,
Sýkora David,
Veselá Kateřina,
Antonyová Veronika,
Dytrych Petr,
IkedaSaito Masao,
Martásek Pavel,
Jakubek Milan
Publication year - 2021
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.13782
Subject(s) - lansoprazole , chemistry , omeprazole , proton pump inhibitor , proton , ion , metal , metal ions in aqueous solution , transition metal , pharmacology , biochemistry , medicine , organic chemistry , physics , quantum mechanics , catalysis
Proton pump inhibitors, such as omeprazole, pantoprazole and lansoprazole, are an important group of clinically used drugs. Generally, they are considered safe without direct toxicity. Nevertheless, their long‐term use can be associated with a higher risk of some serious pathological states (e.g. amnesia and oncological and neurodegenerative states). It is well known that dysregulation of the metabolism of transition metals (especially iron ions) plays a significant role in these pathological states and that the above drugs can form complexes with metal ions. However, to the best of our knowledge, this phenomenon has not yet been described in water systems. Therefore, we studied the interaction between these drugs and transition metal ions in the surrounding water environment (water/DMSO, 99:1, v/v) by absorption spectroscopy. In the presence of Fe(III), a strong redshift was observed, and more importantly, the affinities of the drugs (represented as binding constants) were strong enough, especially in the case of omeprazole, so that the formation of a metallocomplex cannot be excluded during the explanation of their side effects.