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Synthesis of promising antimicrobial agents: hydrazide‐hydrazones of 5‐nitrofuran‐2‐carboxylic acid
Author(s) -
Popiołek Łukasz,
Rysz Bernadetta,
Biernasiuk Anna,
Wujec Monika
Publication year - 2020
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.13639
Subject(s) - hydrazide , nitrofuran , antimicrobial , chemistry , carboxylic acid , nitrofurantoin , combinatorial chemistry , organic chemistry , stereochemistry , antibiotics , biochemistry , antibiotic resistance , biology , genetics
In this research, we synthesized and evaluated for in vitro antimicrobial activity a new series of hydrazide‐hydrazones obtained from 5‐nitrofuran‐2‐carboxylic acid. New compounds were identified and characterized by spectral methods ( 1 H NMR and 13 C NMR). All tested hydrazide‐hydrazones proved to be promising antimicrobial agents. Antimicrobial activity and antifungal activity of new derivatives of 5‐nitrofuran‐2‐carboxylic acid were revealed in many cases to be higher than the activity of reference substances (nitrofurantoin, cefuroxime and ampicillin).