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New fluoroquinolone compounds with endo ‐nortropine derivatives at C‐7 position show antibacterial activity against fluoroquinolone‐resistant strains of Staphylococcus aureus
Author(s) -
Salunke Ramkrushna Ashok,
Shukla Manjulika,
Kaul Grace,
Bansal Baldev Raj,
Chopra Sidharth,
Chhibber Manmohan
Publication year - 2019
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.13513
Subject(s) - staphylococcus aureus , acinetobacter baumannii , klebsiella pneumoniae , pseudomonas aeruginosa , escherichia coli , antibacterial activity , microbiology and biotechnology , chemistry , bacteria , biology , biochemistry , gene , genetics
A series of new fluoroquinolone analogs ( 3 – 18) were prepared, in three steps, by substituting chloro esters and esters with cyclic amines on the C‐7 endo ‐nortropine derivatives of difluoroquinolone acid. All the synthesized compounds displayed good MIC against the Staphylococcus aureus when initially screened for Escherichia coli , S. aureus, Klebsiella pneumoniae , Acinetobacter baumannii, and Pseudomonas aeruginosa . The molecules were further evaluated for their antibacterial activity against fluoroquinolone‐resistant strains of S. aureus and for cytotoxic assay. Based on the results, five of the sixteen compounds displayed the potential to be developed further for treatment against fluoroquinolone‐resistant strains of S. aureus .