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Natural compounds with xanthine oxidase inhibitory activity: A review
Author(s) -
Mehmood Arshad,
Ishaq Muhammad,
Zhao Lei,
Safdar Bushra,
Rehman Ashfaqur,
Munir Masooma,
Raza Ali,
Nadeem Muhammad,
Iqbal Waheed,
Wang Chengtao
Publication year - 2019
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.13437
Subject(s) - xanthine oxidase , hyperuricemia , gout , uric acid , disease , medicine , chemistry , pharmacology , biochemistry , traditional medicine , enzyme
Hyperuricemia ( HUA ), a disease due to an elevation of body uric acid level and responsible for various diseases such as gout, cardiovascular disorders, and renal failure, is a major ground debate for the medical science these days. Considering the risk factors linked with allopathic drugs for the treatment of this disease, the debate has now become a special issue. Previously, we critically discussed the role of dietary polyphenols in the treatment of HUA . Besides dietary food plants, many researchers figure out the tremendous effects of medicinal plants‐derived phytochemicals against HUA . Keeping in mind all these aspects, we reviewed all possible managerial studies related to HUA through medicinal plants (isolated compounds). In the current review article, we comprehensively discussed various bioactive compounds, chemical structures, and structure–activity relationship with responsible key enzyme xanthine oxidase.