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One pot multi‐component synthesis of functionalized spiropyridine and pyrido[2,3‐ d ]pyrimidine scaffolds and their potent in‐vitro anti‐inflammatory and anti‐oxidant investigations
Author(s) -
Lavanya Mallu,
Asharani Indira Viswambaran,
Thirumalai Dhakshanamurthy
Publication year - 2019
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.13434
Subject(s) - chemistry , ascorbic acid , pyrimidine , in vitro , dpph , carbon 13 nmr , proton nmr , combinatorial chemistry , pyridine , stereochemistry , antioxidant , nuclear chemistry , organic chemistry , biochemistry , food science
A new series of functionalized fused pyridines 4(a–i) and fused pyrido[2,3‐d]pyrimidines 8(a–c) were designed and synthesized through a multi‐component reaction where in pyridine ring formation step plays a key role. All the newly formed compounds were well characterized by spectral techniques such as FTIR , 1 HNMR , 13 CNMR , HRMS and XRD . The potential therapeutic activities such as anti‐inflammatory activity by protein denaturation and RBC membrane stabilization methods, and anti‐oxidant activity by DPPH scavenging method of the newly synthesized compounds were studied. Interestingly, in‐vitro testing of these compounds reveals that the compounds 4d , 4g , 4i , 8a and 8b showed comparable anti‐inflammatory activity with respect to the standard drug, diclofenac. Similarly, fused pyridine 4f showed excellent anti‐oxidant activity when compared with the standard, ascorbic acid.