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5‐hydroxymethylfurfural‐ and fluorescein‐fused fluorescence probe of mast cells ( RBL ‐2H3): Synthesis, photophysical properties, and bioimaging
Author(s) -
Huang Limin,
Wei Di,
Wu Zibo,
Hou Yajing,
Xie Yitong,
Liu Zhenru,
Wang Cheng,
Che Delu,
Lei Yibo,
He Huaizhen
Publication year - 2018
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.13367
Subject(s) - fluorescein , fluorescence , chemistry , moiety , biophysics , combinatorial chemistry , stereochemistry , physics , quantum mechanics , biology
A fluorescent probe ( Fluo‐ HMF ) was developed via introduction of a furfural moiety into the fluorescein molecular skeleton, aiming at specially labeling cell membrane of mast cells. To illustrate its specificity, we designed and synthesized a series of fluorescent compounds based on fluorescein molecular skeleton. The fluorescent properties of Fluo‐ HMF were investigated, which were in accordance with theoretical calculations. Compared with other fluorescein derivatives, Fluo‐ HMF could specially label RBL ‐2H3 cells. The results suggested that Fluo‐ HMF could be used as a fluorescent probe for bioimaging on some related research of allergic mechanism.