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The delivery of doxorubicin of multifunctional β‐cyclodextrin‐modified CdSe/ZnS quantum dots for bioactivity and nano‐probing
Author(s) -
Zhao MeiXia,
Zhu BingJie,
Yao WenJing,
Chen DiFeng,
Wang Chaojie
Publication year - 2018
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.13080
Subject(s) - doxorubicin , quantum dot , intracellular , cancer cell , chemistry , apoptosis , fluorescence , biophysics , cyclodextrin , flow cytometry , membrane , drug delivery , nanoparticle , tryptophan , nanotechnology , biochemistry , materials science , cancer , microbiology and biotechnology , biology , organic chemistry , chemotherapy , genetics , physics , quantum mechanics , amino acid
The modified quantum dots ( QD s) have been used in intracellular probing and drug delivery because of their special chemical and physical properties. In this paper, two β‐cyclodextrin (β‐ CD )‐modified CdSe/ZnS QD s with strong optical emission properties were synthesized as drug carriers to induce apoptosis. The positively charged l ‐Arginine ( l ‐Arg) and neutral l ‐Tryptophan ( l ‐Trp) were selected as ligands to compare the effect of charge on bioactivity of QD s nanoparticles. The in vitro assays revealed that these modified QD s showed good Dox carrier ability and significantly high inhibition rate to cancer cells. Especially, the more positively charged β‐ CD ‐ l ‐Arg‐polyamine‐coated CdSe/ZnS QD s could effectively deliver the doxorubicin (Dox) into cells and exhibit excellent cell selectivity in cancer versus normal cells. The Dox‐loaded QD s could enter intracellular, which showed that the Dox can efficiently go through the membranes at the existence of β‐ CD . Several lines of evidence suggest that the Dox‐loaded QD s can efficiently induce apoptosis likely related to the production of ROS . We expect that the modified QD s can enhance the amount of hydrophobic antitumor drugs in cells and can also be used as fluorescent imaging agents.