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Syntheses and structure–membrane active antimicrobial activity relationship of alkylamino‐modified glucose, maltooligosaccharide, and amylose
Author(s) -
Yamamura Hatsuo,
Mabuchi Takahiro,
Ishida Tomoki,
Miyagawa Atsushi
Publication year - 2017
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12989
Subject(s) - antimicrobial , chemistry , polysaccharide , amylose , combinatorial chemistry , chemical modification , biochemistry , structure–activity relationship , membrane , organic chemistry , in vitro , starch
Antimicrobial alkylamine‐modified sugars were prepared. Microwave‐assisted click reaction efficiently achieved poly‐functionalization of oligo‐ and polysaccharides. The sugars exhibited a unique relationship of their bacterial membrane permeabilization and antimicrobial activity with the number of functional groups and the structure of the molecular scaffold. It shows that the assembly of the functional groups is necessary for being antimicrobial. The amylose derivatives also exhibited synergy to minimize the necessary dose of conventional antibiotics and increase their antimicrobial potency.