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1 H ‐1,2,3‐triazole‐tethered uracil‐ferrocene and uracil‐ferrocenylchalcone conjugates: Synthesis and antitubercular evaluation
Author(s) -
Singh Amandeep,
Biot Christophe,
Viljoen Albertus,
Dupont Christian,
Kremer Laurent,
Kumar Kewal,
Kumar Vipan
Publication year - 2017
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12908
Subject(s) - ferrocene , uracil , chemistry , triazole , substituent , cycloaddition , conjugate , click chemistry , chalcone , alkyne , azide , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , biochemistry , dna , mathematics , mathematical analysis , electrode , electrochemistry
Copper‐catalyzed azide‐alkyne [3 + 2] cycloaddition has been utilized for preparing a series of 1 H ‐1,2,3‐triazoles with the purpose of probing structure–activity relationships among a uracil‐ferrocene‐triazole conjugate family. The antitubercular evaluation studies revealed an improvement in activity with the introduction of a ferrocene nucleus among N ‐alkylazido‐uracil precursors, with a preference for a bromo‐substituent along with moderate chain lengths of n = 2–6. The reported protocol is a successful approach for integrating uracil‐ferrocene‐chalcone functionalities tethered via 1 H ‐1,2,3‐triazole rings with apparent physicochemical stability.