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An enzymatic approach to configurationally rare trans ‐androsteronyl‐α‐glucoside and Its potential anticancer application
Author(s) -
Chou FengPai,
Tsai ChiaTse,
Chiou YaSheng,
Chen YiJu,
Li MengErh,
Guo TingWei,
Lyu Jason WenJay,
Chou ShengHao,
Wu TungKung
Publication year - 2017
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12830
Subject(s) - glucoside , enzyme , glycosyltransferase , glycosylation , chemistry , biochemistry , glycoside , stereochemistry , medicine , alternative medicine , pathology
Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP 0421 shows protein plasticity on generation of configurationally rare steryl‐α‐glucosides. Investigation of trans ‐androsteronyl‐α‐glucoside on tamoxifen‐treated MCF ‐7 breast cancer cells shows dose‐dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl‐α‐glucosides with useful biological activities.