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Greener synthesis of indolizine analogues using water as a base and solvent: study for larvicidal activity against Anopheles arabiensis
Author(s) -
Sandeep Chandrashekharappa,
Venugopala Katharigatta N.,
Gleiser Raquel M.,
Chetram Abeen,
Padmashali Basavaraj,
Kulkarni Rashmi S.,
Venugopala Rashmi,
Odhav Bharti
Publication year - 2016
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12823
Subject(s) - solvent , base (topology) , yield (engineering) , chemistry , organic chemistry , traditional medicine , nuclear chemistry , mathematics , materials science , medicine , mathematical analysis , metallurgy
Greener synthesis of a series of novel indolizine analogues have been achieved by the cyclization of aromatic cycloimmonium ylides with electron‐deficient alkynes in the presence of water as the base and solvent at 80 °C. Yield of the title compounds was good and reactions performed were eco‐friendly. The structures of these newly synthesized compounds have been confirmed by spectroscopic techniques such as FTIR , NMR , LC ‐ MS , and elemental analysis. Characterized title compounds were evaluated for larvicidal activity against Anopheles arabiensis by standard WHO larvicidal assay using Temefos as standard at 4 μg/ mL . Title compounds 2e , 2f , and 2g emerged as promising larvicidal agents.