Greener synthesis of indolizine analogues using water as a base and solvent: study for larvicidal activity against Anopheles arabiensis

Greener synthesis of a series of novel indolizine analogues have been achieved by the cyclization of aromatic cycloimmonium ylides with electron‐deficient alkynes in the presence of water as the base and solvent at 80 °C. Yield of the title compounds was good and reactions performed were eco‐friendly. The structures of these newly synthesized compounds have been confirmed by spectroscopic techniques such as FTIR , NMR , LC ‐ MS , and elemental analysis. Characterized title compounds were evaluated for larvicidal activity against Anopheles arabiensis by standard WHO larvicidal assay using Temefos as standard at 4 μg/ mL . Title compounds 2e , 2f , and 2g emerged as promising larvicidal agents.