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Preparation, characterization, and cytotoxic effects of liposomal nanoparticles containing cisplatin: an in vitro study
Author(s) -
Poy Donya,
Akbarzadeh Azim,
Ebrahimi Shahmabadi Hasan,
Ebrahimifar Meysam,
Farhangi Ali,
Farahnak Zarabi Maryam,
Akbari Azam,
Saffari Zahra,
Siami Fatemeh
Publication year - 2016
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12786
Subject(s) - cisplatin , cytotoxicity , zeta potential , nanoparticle , drug , liposome , chemistry , drug delivery , in vitro , pharmacology , potency , nanotechnology , materials science , chemotherapy , biochemistry , medicine , surgery
Cisplatin is a chemotherapeutic agent used for treating various malignancies. The study aimed to prepare pegylated liposomal cisplatin and evaluate its efficacy against human breast cancer cell line MCF ‐7. Drug‐loaded nanoparticles were synthesized by reverse phase evaporation technique. The study is highlighted by extensive characterization of nanoparticles in terms of nanoparticle morphology, type of drug entrapment, cisplatin retention capability, and cytotoxicity effects. The size, size distribution, and zeta potential of nanodrug were estimated 142 nm, 0.33, and −22 mV, respectively. Drug‐loading efficiency was equal to 48% that occurred physically. Furthermore, high retention capability (39% of drug was released after 72 h) with significantly enhanced cytotoxicity of nanodrug (1.75 times more than the standard drug) confirmed the potency of liposomal nanoparticles as proper cisplatin carrier.