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Synthesis and biological evaluation of novel lignan glycosides as anticancer agents
Author(s) -
Wang Ying,
Xia Chao,
Zhang Wei,
Zhao Yu
Publication year - 2016
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12785
Subject(s) - lignan , cytotoxicity , glycoside , chemistry , stereochemistry , cancer cell lines , lysosome , biochemistry , cancer cell , cancer , in vitro , biology , enzyme , genetics
Novel lignan glycosides 1a – 1 h as analogues of cleistanthin A were designed and synthesized. Most of these compounds displayed significant cytotoxicities against four cancer cell lines. Compound 1e displayed better cytotoxicity than cleistanthin A with IC 50 values from 1.0 n m to 8.3 n m . Further lysosome acidity assay disclosed that 1e could totally inhibit the activity of V‐ ATP ase at 60 n m .
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