Premium
Synthesis, Polymorphism, and Insecticidal Activity of Methyl 4‐(4‐chlorophenyl)‐8‐iodo‐2‐methyl‐6‐oxo‐1,6‐dihydro‐4 H ‐pyrimido[2,1‐ b ]quinazoline‐3‐Carboxylate Against Anopheles arabiensis Mosquito
Author(s) -
Venugopala Katharigatta N.,
Nayak Susanta K.,
Gleiser Raquel M.,
SanchezBorzone Mariela E.,
Garcia Daniel A.,
Odhav Bharti
Publication year - 2016
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12736
Subject(s) - quinazoline , chemistry , carboxylate , stereochemistry , medicinal chemistry
Mosquitoes are the major vectors of pathogens and parasites including those causing malaria, the most deadly vector‐borne disease. The negative environmental effects of most synthetic compounds combined with widespread development of insecticide resistance encourage an interest in finding and developing alternative products against mosquitoes. In this study, pyrimido[2,1‐ b ]quinazoline derivative DHPM 3 has been synthesized by three‐step chemical reaction and screened for larvicide, adulticide, and repellent properties against Anopheles arabiensis, one of the dominant vectors of malaria in Africa. The title compound emerged as potential larvicide agent for further research and development, because it exerted 100% mortality, while adulticide activity was considered moderate.