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Synthesis of New ‘Hybrid’ Compounds Based on Benzofuroxans and Aminoalkylnaphthalimides
Author(s) -
Chugunova Elena,
Mukhamatdinova Rezeda,
Sazykina Marina,
Dobrynin Alexey,
Sazykin Ivan,
Karpenko Alexander,
Mirina Elena,
Zhuravleva Maria,
Gavrilov Nikolai,
Karchava Shorena,
Burilov Alexander
Publication year - 2016
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12685
Subject(s) - pharmacophore , combinatorial chemistry , chemistry , bacteria , antibacterial activity , biological activity , pathogenic bacteria , computational biology , biochemical engineering , nanotechnology , stereochemistry , biology , biochemistry , materials science , in vitro , genetics , engineering
Pathogenic bacteria and fungi eventually develop resistance to existing drugs, and therefore, we need constant development of new drugs. The research is aimed at addressing fundamental scientific problems—the search for new biologically active compounds among several benzofuroxan‐containing ‘hybrid’ products. N ‐substituted naphthalimides were chosen as a second pharmacophore. Benzofuroxanes biological effects were studied by means of bacterial lux‐biosensors. Compounds III a, IV a, III c, and IV c displayed more expressed bacteriotoxic action in comparison with the initial substances Ia‐c and represent a certain interest for using as antibacterial substances.