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Synthesis and In Vitro Activity of Polyhalogenated 2‐phenylbenzimidazoles as a New Class of anti‐ MRSA and Anti‐ VRE Agents
Author(s) -
Göker Hakan,
Karaaslan Cigdem,
Püsküllü Mustafa Orhan,
Yildiz Sulhiye,
Duydu Yalcin,
Üstündağ Aylin,
Yalcin Can Özgür
Publication year - 2016
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12623
Subject(s) - enterococcus faecium , staphylococcus aureus , microbiology and biotechnology , vancomycin , enterococcus , in vitro , antibiotics , chemistry , methicillin resistant staphylococcus aureus , minimum inhibitory concentration , bacteria , biology , biochemistry , genetics
A series of novel polyhalogenated 2‐phenylbenzimidazoles have been synthesized and evaluated for in vitro antistaphylococcal activity against drug‐resistant bacterial strains (methicillin‐resistant Staphylococcus aureus, and vancomycin‐resistant Enterococcus faecium . Certain compounds inhibit bacterial growth perfectly. 11 was active than vancomycin (0.78 μ g/ mL ) with the lowest MIC values with 0.19 μ g/ mL against methicillin‐resistant Staphylococcus aureus , 8 and 35 exhibited best inhibitory activity against vancomycin‐resistant Enterococcus faecium (1.56 μ g/ mL ). The mechanism of action for this class of compounds appears to be different than clinically used antibiotics. These polyhalogenated benzimidazoles have potential for further investigation as a new class of potent anti‐methicillin‐resistant Staphylococcus aureus and anti‐vancomycin‐resistant Enterococcus faecium agents.
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