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Synthesis of Novel 3‐aryl‐1‐oxa‐2,8‐diazaspiro[4.5]dec‐2‐ene Derivatives and Their Biological Evaluation Against Protein Tyrosine Phosphatase 1B
Author(s) -
Wang WenLong,
Chen Xia,
Gao LiXin,
Sheng Li,
Li JingYa,
Li Jia,
Feng Bainian
Publication year - 2015
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12587
Subject(s) - aryl , protein tyrosine phosphatase , phosphatase , chemistry , protein phosphatase 2 , tyrosine , ic50 , lead compound , stereochemistry , biochemistry , enzyme , in vitro , organic chemistry , alkyl
A series of novel 3‐aryl‐1‐oxa‐2,8‐diazaspiro[4.5]dec‐2‐ene derivatives were designed, synthesized, and evaluated as a new class of inhibitors against protein tyrosine phosphatase 1B. Among them, compound 6f displayed moderate inhibitory activity with IC 50 of 2.87 ± 0.24 μ m and can be used as a novel lead compound for the design of inhibitors of protein tyrosine phosphatase 1B.