Premium
Screening Feature Genes of Venous Thromboembolism with DNA Microarray
Author(s) -
Zhou Tao,
Zhang Yudong,
Wu Peng,
Sun Qiang,
Guo Yanan
Publication year - 2015
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12557
Subject(s) - gene , biology , ribosome , translation (biology) , gene expression , computational biology , microbiology and biotechnology , genetics , rna , messenger rna
We aimed to explore the potential genes or pathways related to venous thromboembolism ( VTE ) and expected our findings could contribute to the development of new target drugs for VTE . The gene expression profile of GSE 19151 was downloaded from Gene Expression Omnibus ( GEO ) database. The bioinformatics methods were applied to screen the feature genes and pathways related with VTE . A total of 115 DEG s were identified, including 25 downregulated genes and 90 upregulated genes. Function enrichment analysis showed that upregulated genes of VTE were mainly enriched in ribosome and translation‐related pathways, while downregulated genes were mainly enriched in cytoskeletal protein binding and non‐membrane‐bounded organelle‐related pathways. MCL 1 , TP 53, and RERE were three outstanding genes involved in the interaction network. The most significant pathways enriched by module genes were ribosome and oxidative phosphorylation. Moreover, all the products of the 18 genes enriched in ribosome (hsa03010) were ribosomal proteins. Ribosome, translation, actin binding, and non‐membrane‐bounded organelle pathways were closely related to the development of VTE . Moreover, MCL 1, TP 53, and RERE might play key roles in the process of VTE .