Inhibition of Acetylcholinesterase ( AC hE): A Potential Therapeutic Target to Treat Alzheimer's Disease | Zendy

Li Yong | Zendy; Zhang Xiaoxiao | Zendy; Jiang Lijuan | Zendy; Yuan Li | Zendy; Cao Tingting | Zendy; Li Xia | Zendy; Dong Lin | Zendy; Li Ying | Zendy; Yin ShuFan | Zendy

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Inhibition of Acetylcholinesterase ( AC hE): A Potential Therapeutic Target to Treat Alzheimer's Disease

Author(s) -

Li Yong,

Zhang Xiaoxiao,

Jiang Lijuan,

Yuan Li,

Cao Tingting,

Li Xia,

Dong Lin,

Li Ying,

Yin ShuFan

Publication year - 2015

Publication title -

chemical biology and drug design

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.59

H-Index - 77

eISSN - 1747-0285

pISSN - 1747-0277

DOI - 10.1111/cbdd.12550

Subject(s) - icariin , acetylcholinesterase , aché , pharmacology , chemistry , in vitro , inhibitory postsynaptic potential , toxicity , biochemistry , enzyme , medicine , alternative medicine , pathology , organic chemistry

A new series of icariin derivatives were synthesized and evaluated for their in vitro acetylcholinesterase ( AC hE) inhibitory activity. Most of the tested compounds exhibited high AC hE inhibition and low toxicity, and among which compounds 1 , 2 , and 10 were the most potent ( IC 50 = 71.52 ± 22.43, 8.28 ± 1.45, 5.830 ± 1.78 n m , respectively).

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