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Improving the Tuberculosis Drug Development Pipeline
Author(s) -
Evangelopoulos Dimitrios,
McHugh Timothy D.
Publication year - 2015
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12549
Subject(s) - tuberculosis , mycobacterium tuberculosis , drug discovery , drug development , drug , medicine , disease , pipeline (software) , intensive care medicine , pharmacology , bioinformatics , biology , computer science , pathology , programming language
Mycobacterium tuberculosis is considered one of the most successful pathogens and multidrug‐resistant tuberculosis, a disease that urgently requires new chemical entities to be developed for treatment. There are currently several new molecules under clinical investigation in the tuberculosis (TB) drug development pipeline. However, the complex lifestyle of M. tuberculosis within the host presents a barrier to the development of new drugs. In this review, we highlight the reasons that make TB drug discovery and development challenging as well as providing solutions, future directions and alternative approaches to new therapeutics for TB .