Design, Synthesis, and Biological Evaluation of  γ ‐Aminopropyl Silatrane–Acyclovir Hybrids with Immunomodulatory Effects | Zendy

Ye Faqing | Zendy; Song Xiaoqin | Zendy; Liu Jianmin | Zendy; Xu Xuemei | Zendy; Wang Yuewu | Zendy; Hu Lichuan | Zendy; Wang Yi | Zendy; Liang Guang | Zendy; Guo Ping | Zendy; Xie Zixin | Zendy

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Design, Synthesis, and Biological Evaluation of γ ‐Aminopropyl Silatrane–Acyclovir Hybrids with Immunomodulatory Effects

Author(s) -

Ye Faqing,

Song Xiaoqin,

Liu Jianmin,

Xu Xuemei,

Wang Yuewu,

Hu Lichuan,

Wang Yi,

Liang Guang,

Guo Ping,

Xie Zixin

Publication year - 2015

Publication title -

chemical biology and drug design

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.59

H-Index - 77

eISSN - 1747-0285

pISSN - 1747-0277

DOI - 10.1111/cbdd.12519

Subject(s) - in vivo , in vitro , chemistry , potency , stereochemistry , immune system , biological activity , proton nmr , herpes simplex virus , combinatorial chemistry , biochemistry , virus , virology , biology , immunology , microbiology and biotechnology

Several derivatives of γ ‐aminopropyl silatrane containing acyclovir in their molecular structure were synthesized and evaluated for their immunomodulatory and antiviral activities. The structures of all these derivatives were confirmed by mass spectra, IR , and 1 H NMR . Based on WST ‐1 assay in vitro , these compounds could stimulate proliferation of splenic lymphocytes at certain concentrations. Furthermore, compound 3d could also potentiate the expression of IFN ‐ γ , IL ‐2, CD 4 + , CD 8 + , and CD 4 + / CD 8 + in vivo . Our results show that these derivatives possess antiviral activity against herpes simplex viruses with a similar potency to acyclovir without a cellular immune response.

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