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Design, Synthesis, and Biological Evaluation of γ ‐Aminopropyl Silatrane–Acyclovir Hybrids with Immunomodulatory Effects
Author(s) -
Ye Faqing,
Song Xiaoqin,
Liu Jianmin,
Xu Xuemei,
Wang Yuewu,
Hu Lichuan,
Wang Yi,
Liang Guang,
Guo Ping,
Xie Zixin
Publication year - 2015
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12519
Subject(s) - in vivo , in vitro , chemistry , potency , stereochemistry , immune system , biological activity , proton nmr , herpes simplex virus , combinatorial chemistry , biochemistry , virus , virology , biology , immunology , microbiology and biotechnology
Several derivatives of γ ‐aminopropyl silatrane containing acyclovir in their molecular structure were synthesized and evaluated for their immunomodulatory and antiviral activities. The structures of all these derivatives were confirmed by mass spectra, IR , and 1 H NMR . Based on WST ‐1 assay in vitro , these compounds could stimulate proliferation of splenic lymphocytes at certain concentrations. Furthermore, compound 3d could also potentiate the expression of IFN ‐ γ , IL ‐2, CD 4 + , CD 8 + , and CD 4 + / CD 8 + in vivo . Our results show that these derivatives possess antiviral activity against herpes simplex viruses with a similar potency to acyclovir without a cellular immune response.