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Quantitative Relationships Between the Cytotoxicity of Flavonoids on the Human Breast Cancer Stem‐Like Cells MCF 7‐ SC and Their Structural Properties
Author(s) -
Jung Hyeryoung,
Shin Soon Young,
Jung Yearam,
Tran Thao Anh,
Lee Hye Ok,
Jung KangYeoun,
Koh Dongsoo,
Cho Somi Kim,
Lim Yoongho
Publication year - 2015
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12512
Subject(s) - cytotoxicity , cancer stem cell , stem cell , cytotoxic t cell , flow cytometry , breast cancer , metastasis , cancer , cancer research , western blot , biology , cancer cell , chemistry , microbiology and biotechnology , biochemistry , in vitro , genetics , gene
As some breast cancer‐related deaths can be attributed to the metastasis of cancer stem cells, chemotherapeutic agents targeting breast cancer stem cells are of interest as a potential treatment. Flavonoids that exhibit cytotoxicity on breast cancer stem cells have rarely been observed. Thus, the objective of this study was to measure potential cytotoxic effects of 42 different flavonoids on the human breast cancer stem‐like cell line, MCF 7‐ SC . The relationship between flavonoid structural properties and cytotoxicity has not been reported previously; therefore, we determined quantitative structure–activity relationships using both comparative molecular field analysis and comparative molecular similarity analysis. Further biological experiments including Western blot analysis, flow cytometry, and immunofluorescence microscopy were also conducted on the most cytotoxic 8‐chloroflavanone.