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A High‐Sensitivity Coumarin‐Based Fluorescent Probe for Monitoring Hydrogen Sulfide in Living Cells
Author(s) -
Qiu Qianqian,
Deng Xin,
Jiao Lei,
Zhao Tianxiao,
Meng Fanfei,
Huang Wenlong,
Qian Hai
Publication year - 2015
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12483
Subject(s) - hydrogen sulfide , coumarin , fluorescence , chemistry , selectivity , photochemistry , sulfide , detection limit , combinatorial chemistry , sulfur , chromatography , biochemistry , organic chemistry , catalysis , physics , quantum mechanics
A novel coumarin‐based fluorescence probe has been constructed for the selective and sensitive detection of hydrogen sulfide (H 2 S). This probe displays high sensitivity and linearity to H 2 S in degassed PBS buffers and fetal bovine serum. It reacts with H 2 S with high selectivity over Cys, GSH , and other anions. Meanwhile, successful detection of H 2 S in living cells was also demonstrated.