A High‐Sensitivity Coumarin‐Based Fluorescent Probe for Monitoring Hydrogen Sulfide in Living Cells | Zendy

Qiu Qianqian | Zendy; Deng Xin | Zendy; Jiao Lei | Zendy; Zhao Tianxiao | Zendy; Meng Fanfei | Zendy; Huang Wenlong | Zendy; Qian Hai | Zendy

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A High‐Sensitivity Coumarin‐Based Fluorescent Probe for Monitoring Hydrogen Sulfide in Living Cells

Author(s) -

Qiu Qianqian,

Deng Xin,

Jiao Lei,

Zhao Tianxiao,

Meng Fanfei,

Huang Wenlong,

Qian Hai

Publication year - 2015

Publication title -

chemical biology and drug design

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.59

H-Index - 77

eISSN - 1747-0285

pISSN - 1747-0277

DOI - 10.1111/cbdd.12483

Subject(s) - hydrogen sulfide , coumarin , fluorescence , chemistry , selectivity , photochemistry , sulfide , detection limit , combinatorial chemistry , sulfur , chromatography , biochemistry , organic chemistry , catalysis , physics , quantum mechanics

A novel coumarin‐based fluorescence probe has been constructed for the selective and sensitive detection of hydrogen sulfide (H 2 S). This probe displays high sensitivity and linearity to H 2 S in degassed PBS buffers and fetal bovine serum. It reacts with H 2 S with high selectivity over Cys, GSH , and other anions. Meanwhile, successful detection of H 2 S in living cells was also demonstrated.

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