A Bifurcated Proteoglycan Binding Small Molecule Carrier for si RNA  Delivery | Zendy

Gooding Matt | Zendy; Adigbli Derick | Zendy; Edith Chan A. W. | Zendy; Melander Roberta J. | Zendy; MacRobert Alexander J. | Zendy; Selwood David L. | Zendy

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A Bifurcated Proteoglycan Binding Small Molecule Carrier for si RNA Delivery

Author(s) -

Gooding Matt,

Adigbli Derick,

Edith Chan A. W.,

Melander Roberta J.,

MacRobert Alexander J.,

Selwood David L.

Publication year - 2014

Publication title -

chemical biology and drug design

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.59

H-Index - 77

eISSN - 1747-0285

pISSN - 1747-0277

DOI - 10.1111/cbdd.12295

Subject(s) - proteoglycan , gene knockdown , lipofectamine , messenger rna , peptide , microbiology and biotechnology , chemistry , biophysics , small interfering rna , microrna , small molecule , transfection , biochemistry , biology , gene , recombinant dna , vector (molecular biology) , extracellular matrix

A wider application of si RNA ‐ and mi RNA ‐ based therapeutics is restricted by the currently available delivery systems. We have designed a new type of small molecule carrier ( SM o C ) system for si RNA modeled to interact with cell surface proteoglycans. This bifurcated SM o C has similar affinity for the model proteoglycan heparin to an equivalent polyarginine peptide and exhibits significant mRNA knockdown of protein levels comparable to lipofectamine and the previously reported linear SM o C .

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