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A Bifurcated Proteoglycan Binding Small Molecule Carrier for si RNA Delivery
Author(s) -
Gooding Matt,
Adigbli Derick,
Edith Chan A. W.,
Melander Roberta J.,
MacRobert Alexander J.,
Selwood David L.
Publication year - 2014
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12295
Subject(s) - proteoglycan , gene knockdown , lipofectamine , messenger rna , peptide , microbiology and biotechnology , chemistry , biophysics , small interfering rna , microrna , small molecule , transfection , biochemistry , biology , gene , recombinant dna , vector (molecular biology) , extracellular matrix
A wider application of si RNA ‐ and mi RNA ‐ based therapeutics is restricted by the currently available delivery systems. We have designed a new type of small molecule carrier ( SM o C ) system for si RNA modeled to interact with cell surface proteoglycans. This bifurcated SM o C has similar affinity for the model proteoglycan heparin to an equivalent polyarginine peptide and exhibits significant mRNA knockdown of protein levels comparable to lipofectamine and the previously reported linear SM o C .