Unsymmetrical Oxovanadium Complexes Derived from Salicylaldehyde and Phenanthroline: Synthesis,  DNA  Interactions, and Antitumor Activities | Zendy

Liao Xiangwen | Zendy; Pan Weijian | Zendy; He Rongwei | Zendy; Guo Haiwei | Zendy; Ying Peng | Zendy; Lu Jiazheng | Zendy

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Unsymmetrical Oxovanadium Complexes Derived from Salicylaldehyde and Phenanthroline: Synthesis, DNA Interactions, and Antitumor Activities

Author(s) -

Liao Xiangwen,

Pan Weijian,

He Rongwei,

Guo Haiwei,

Ying Peng,

Lu Jiazheng

Publication year - 2014

Publication title -

chemical biology and drug design

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.59

H-Index - 77

eISSN - 1747-0285

pISSN - 1747-0277

DOI - 10.1111/cbdd.12248

Subject(s) - salicylaldehyde , apoptosis , chemistry , anthranilic acid , dna , phenanthroline , annexin , cell cycle , stereochemistry , microbiology and biotechnology , cell cycle checkpoint , cell culture , cytotoxic t cell , biochemistry , biology , crystallography , in vitro , schiff base , genetics

Two unsymmetrical oxovanadium complexes incorporating salicylaldehyde derivate and phenanthroline [ VO ( DESAA )(phen)] ( 1 ), ( DESAA = 4‐(diethylamino)salicylaldehyde anthranilic acid, phen = phenanthroline) and [ VO ( CLSAA )(phen)] ( 2 ), ( CLSAA = 5‐chlorosalicylaldehyde anthranilic acid)] have been synthesized and characterized. The interactions of the complexes with CT ‐ DNA were studied using different techniques. Complexes 1 and 2 interact with CT ‐ DNA by intercalative modes and can efficiently cleave pBR 322 DNA after light irradiation. The two complexes showed high cytotoxic activities against myeloma cell ( A g8.653) and gliomas cell ( U 251) lines. Interestingly, complex 1 exhibited greater antitumor efficiency, larger binding affinity with CT ‐ DNA , and better cleaving ability than those of complex 2 . In addition, their antitumor mechanism has been analyzed by using cell cycle analysis, apoptosis, and Annexin V ‐ FITC / PI assay. The results showed that complex 1 can cause G 2/ M ‐phase arrest of the cell cycle, exhibit a significantly induced apoptosis in A g8.653 cells, and display typical morphological apoptotic characteristics. These complexes induced proliferative suppression of A g8.653 cells via the induction of apoptosis.

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