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A New i , i + 3 Peptide Stapling System for α‐Helix Stabilization
Author(s) -
Shim So Youn,
Kim YoungWoo,
Verdine Gregory L.
Publication year - 2013
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12231
Subject(s) - scope (computer science) , peptide , helix (gastropod) , hydrocarbon , chemistry , carbon atom , stereochemistry , combinatorial chemistry , computer science , biochemistry , biology , organic chemistry , ring (chemistry) , snail , programming language , ecology
We have previously shown that the incorporation of an 8‐atom all‐hydrocarbon ‘staple’ at positions i and i + 3 of a synthetic peptide results in substantial stabilization of the α‐helical conformation. As part of our ongoing effort to explore the scope and utility of all‐hydrocarbon stapling systems, we have investigated and report herein the properties of a new i , i + 3 stapling system that employs a 6‐carbon cross‐link.