Premium
Synthesis, Analytical Analysis, and Medicinal Aspect of Novel Benzimidazoles and their Metal Complexes
Author(s) -
Agrawal Sangeeta,
Bhatnagar Rishi Raj,
Tiwari Anjani,
Srivastava Rakesh,
sharma Upasana
Publication year - 2013
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12201
Subject(s) - benzimidazole , cholecystokinin , binding affinities , biodistribution , chemistry , cholecystokinin receptor , combinatorial chemistry , antagonist , stereochemistry , receptor , biochemistry , organic chemistry , in vitro
Benzimidazole and their metal analogs that can act as multimodal agent and have non‐peptidic CCK ‐B receptor antagonist were synthesized and characterized on the basis of spectroscopic techniques such as FT ‐ IR , NMR , FAB ‐ MS and also evaluated for biologic efficacy. The ligands showed binding to most of the organs, known to express CCK receptors in biodistribution studies. Cholecystokinin ( CCK 1 and CCK 2 ) receptor binding affinities of these analogs ( IC 50 ) are 0.802 ± 0.007 for compound C and 0.326 ± 0.012 for compound D in rat pancreatic acini. These studies have provided a new template for further development of novel agents for various related diseases.