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Cantharidin‐Based Small Molecules as Potential Therapeutic Agents
Author(s) -
Puerto Galvis Carlos E.,
Vargas Méndez Leonor Y.,
Kouznetsov Vladimir V.
Publication year - 2013
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12180
Subject(s) - cantharidin , small molecule , chemistry , pharmacology , computational biology , medicine , biology , biochemistry , organic chemistry
Chemical and pharmacological information on cantharidin‐based small molecules was analyzed. The review summarizes new facts about blister beetles' metabolites for the period 2006–2012. General synthetic approaches to cantharidin‐based small molecules as well as their chemical transformations and biological activities related to cantharidin, norcantharidin, cantharidimide, and norcantharimide analogs, especially their inhibitory activity of phosphoprotein phosphatases in cancer treatment, were discussed in this mini review, which could help to design new small molecule modulators for other biological models.