Inhibitors of Apoptotic Proteins: New Targets for Anticancer Therapy | Zendy

Saleem Mohammad | Zendy; Qadir Muhammad Imran | Zendy; Perveen Nadia | Zendy; Ahmad Bashir | Zendy; Saleem Uzma | Zendy; Irshad Tehseen | Zendy

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Inhibitors of Apoptotic Proteins: New Targets for Anticancer Therapy

Author(s) -

Saleem Mohammad,

Qadir Muhammad Imran,

Perveen Nadia,

Ahmad Bashir,

Saleem Uzma,

Irshad Tehseen

Publication year - 2013

Publication title -

chemical biology and drug design

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.59

H-Index - 77

eISSN - 1747-0285

pISSN - 1747-0277

DOI - 10.1111/cbdd.12176

Subject(s) - xiap , survivin , inhibitor of apoptosis , apoptosis , caspase , microbiology and biotechnology , cancer research , biology , chemistry , programmed cell death , biochemistry

Inhibitors of apoptotic proteins ( IAP s) can play an important role in inhibiting apoptosis by exerting their negative action on caspases (apoptotic proteins). There are eight proteins in this family: NAIP / BIRC 1/ NLRB , cellular IAP 1 ( cIAP 1)/human IAP 2/ BIRC 2, cellular IAP 2 ( cIAP 2)/human IAP 1/ BIRC 3, X ‐linked IAP ( XIAP )/ BIRC 4, survivin/ BIRC 5, baculoviral IAP repeat ( BIR )‐containing ubiquitin‐conjugating enzyme/apollon/ BIRC 6, livin/melanoma‐ IAP ( ML ‐ IAP )/ BIRC 7/ KIAP , and testis‐specific IAP ( T s‐ IAP )/ hILP ‐2/ BIRC 8. Deregulation of these inhibitors of apoptotic proteins ( IAP s) may push cell toward cancer and neurodegenerative disorders. Inhibitors of apoptotic proteins ( IAP s) may provide new target for anticancer therapy. Drugs may be developed that are inhibiting these IAP s to induce apoptosis in cancerous cells.

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