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Serendipitous Discovery of a Prodrug of a PARP ‐1 Inhibitor
Author(s) -
Dunn Derek,
Husten Jean,
Aimone Lisa D.,
Ator Mark A.,
Chatterjee Sankar
Publication year - 2013
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12165
Subject(s) - prodrug , parp inhibitor , drug discovery , poly adp ribose polymerase , chemistry , pharmacology , computational biology , biochemistry , medicine , biology , enzyme , polymerase
During SAR development of previously reported pyrrolocarbazole 1 , a potent PARP ‐1 inhibitor, compound 14 , was discovered serendipitously to be a prodrug of compound 1 .