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Evaluation of Hypoglycemic and Antioxidative Effects of Synthesized Peptide MC 62
Author(s) -
Yang Baowei,
Chen Wei,
Jin Jing,
Mei Yicheng,
Wang Xuekun,
Chen Hong,
Yan Sijia,
Ru Meng,
Gu Guolong,
Deng Xin,
Qian Hai,
Huang Wenlong
Publication year - 2013
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12137
Subject(s) - exenatide , streptozotocin , diabetes mellitus , oxidative stress , islet , medicine , endocrinology , oxidative damage , pharmacology , type 2 diabetes
Diabetes mellitus has been considered as a major health problem in the world today. This study aimed to investigate the hypoglycemic and antioxidative effects of peptide MC 62 which was synthesized by solid‐phase peptide synthesis method against diabetes induced by streptozotocin. MC 62 was administered daily and injected intraperitoneally to the diabetic mice at a dose of 1 μmol/kg body weight for 20 days. The levels of fasting blood glucose and H b A 1 C , pancreatic islet damage, and associated changes in antioxidative activities were evaluated in streptozotocin‐induced diabetic mice used the exenatide as positive control. After the administration of MC 62 together with exenatide for 20 days, the elevated fasting blood glucose and H b A 1 C levels were reduced, and antioxidative activities were restored. It was confirmed with the histological finding that MC 62 prevented the islet from damage in diabetic mice. This indicated that MC62 can prevent mice from hyperglycemia which may be associated with oxidative stress. It also suggested that MC62 could be used as a safe alternative hypoglycemic candidate for treatment of diabetes.