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Synthesis and Antimalarial Bioassay of Quinine – Peptide Conjugates
Author(s) -
Panda Siva S.,
Ibrahim Mohamed A.,
Küçükbay Hasan,
Meyers Marvin J.,
Sverdrup Francis M.,
ElFeky Said A.,
Katritzky Alan R.
Publication year - 2013
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12134
Subject(s) - bioassay , quinine , conjugate , malaria , plasmodium falciparum , peptide , chemistry , antimalarial agent , pharmacology , combinatorial chemistry , biology , biochemistry , immunology , mathematics , mathematical analysis , genetics
Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52–95% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC 50 values below 100 n m , similar to quinine.