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1,3,4‐Thiadiazole and its Derivatives: A Review on Recent Progress in Biological Activities
Author(s) -
Jain Abhishek Kumar,
Sharma Simant,
Vaidya Ankur,
Ravichandran Veerasamy,
Agrawal Ram Kishore
Publication year - 2013
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12125
Subject(s) - antimicrobial , chemistry , nucleus , drug , combinatorial chemistry , computational biology , pharmacology , biology , neuroscience , organic chemistry
The 1,3,4‐thiadiazole nucleus is one of the most important and well‐known heterocyclic nuclei, which is a common and integral feature of a variety of natural products and medicinal agents. Thiadiazole nucleus is present as a core structural component in an array of drug categories such as antimicrobial, anti‐inflammatory, analgesic, antiepileptic, antiviral, antineoplastic, and antitubercular agents. The broad and potent activity of thiadiazole and their derivatives has established them as pharmacologically significant scaffolds. In this study, an attempt has been made with recent research findings on this nucleus, to review the structural modifications on different thiadiazole derivatives for various pharmacological activities.