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Chiral Bicyclic Tetramates as Non‐Planar Templates for Chemical Library Synthesis
Author(s) -
Anwar Muhammad,
Moloney Mark G.
Publication year - 2013
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12110
Subject(s) - template , bicyclic molecule , thiazolidine , combinatorial chemistry , chemistry , stereochemistry , bioassay , nanotechnology , biology , materials science , genetics
Chemoselective D ieckmann cyclization reactions may be used on oxazolidine and thiazolidine templates derived from various aldehydes to access bicyclic tetramates, which have potential as templates for chemical library construction. Bioassay against S taphylococcus aureus and E scherichia coli showed that these systems have little or no intrinsic antibacterial bioactivity.