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Optimization of Antimalarial Activity of Synthetic Prodiginines: QSAR , GUSAR , and Co MFA analyses
Author(s) -
Masand Vijay H.,
Mahajan Devidas T.,
Patil Komalsing N.,
Hadda Taibi B.,
Youssoufi Moulay H.,
Jawarkar Rahul D.,
Shibi Indira G.
Publication year - 2013
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12099
Subject(s) - quantitative structure–activity relationship , lipophilicity , chemistry , steric effects , stereochemistry , biological system , biology
In the present study, we have carried out extensive General Unrestricted Structure–Activity Relationships, conventional 3D‐Quantitative Structure–Activity Relationships, and Co MFA analyses of synthetic prodiginines displaying moderate to high activities against Plasmodium Falciperum . 2D and 3D descriptors, various statistical parameters viz. R 2 , R 2 adj , standard error, Y‐randomization, etc., were checked to build fruitful 3D‐Quantitative Structure–Activity Relationships model. The best five parametric 3D‐Quantitative Structure–Activity Relationships model is with R 2 = 0.924 and R 2 pred = 0.901. Co MFA was performed to check the electrostatic and steric regions, which affect the activity. The Co MFA model is graphically inferred using contour plots, which provide insight into the structural requirements for increasing the activity of a compound. The General Unrestricted Structure–Activity Relationships model, with R 2 = 0.940 and Q 2 = 0.912, suggests that the presence of F on aromatic ring is good for activity. The analyses reveal that lipophilicity plays a crucial role in deciding the activity for these molecules.