Premium
Boron‐Containing Peptidomimetics – A Novel Class of Selective Anti‐tubercular Drugs
Author(s) -
Gorovoy Alexey S.,
Gozhina Olga V.,
Svendsen John S.,
Domorad Anna A.,
Tetz George V.,
Tetz Victor V.,
Lejon Tore
Publication year - 2013
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12091
Subject(s) - peptidomimetic , mycobacterium tuberculosis , combinatorial chemistry , antimicrobial , antibiotics , chemistry , tuberculosis , boron , in vitro , human immunodeficiency virus (hiv) , stereochemistry , pharmacology , biochemistry , biology , medicine , organic chemistry , virology , peptide , pathology
Medical treatment for tuberculosis is complicated nowadays by the appearance of new multiresistant strains, and therefore, new antibiotics are in great need. Here, we report the synthesis and in vitro testing of a new class of highly selective antimicrobial boron‐containing peptidomimetics with compounds exhibiting activity against Mycobacterium tuberculosis at ≤5 μg/mL. The new approach developed makes it possible to synthesize variously substituted β‐aminoboronic acids and their derivatives with a high level of diastereoselectivity.