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Aryl‐Heteroaryl Derivatives as Novel Wake‐Promoting Agents
Author(s) -
Lesur Brigitte,
Lin Yin G.,
Marcy Val R.,
Aimone Lisa D.,
Gruner John,
Bacon Edward R.,
Chatterjee Sankar
Publication year - 2013
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12083
Subject(s) - aryl , wakefulness , enantiomer , combinatorial chemistry , wake , chemistry , pharmacology , neuroscience , stereochemistry , psychology , medicine , organic chemistry , electroencephalography , physics , alkyl , thermodynamics
In search of a next generation molecule to the novel wake‐promoting agent modafinil, a series of aryl‐heteroayl‐derived wakefulness enhancing agents (in rats) was developed. From this work, compound 16 was separated into its enantiomers to profile them individually.