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Synthesis and Biological Evaluation of Coumarin Derivatives as Inhibitors of Mycobacterium bovis (BCG)
Author(s) -
Rezayan Ali Hossein,
Azerang Parisa,
Sardari Soroush,
Sarvary Afshin
Publication year - 2012
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.12044
Subject(s) - coumarin , mycobacterium bovis , chemistry , microbiology and biotechnology , biochemistry , biology , combinatorial chemistry , tuberculosis , mycobacterium tuberculosis , organic chemistry , medicine , pathology
The coumarin compounds are an important class of biologically active molecules, which have attractive caught the attention of many organic and medicinal chemists, due to potential pharmaceutical implications and industrial applications. We herein report the one‐pot procedure for the efficient synthesis of coumarin derivatives using commercially available substrates via isocyanide‐based multicomponent condensation reactions. These compounds were evaluated for anti‐mycobacterium activity against Mycobacterium bovis ( Bacillus Calmette–Guerin ). The preliminary results indicated that all of the tested compounds showed relatively good activity against the test organism. The compounds 7e , 7l , and 7m showed high anti‐tuberculosis activity.