Open AccessmiR‐30e‐5p represses angiogenesis and metastasis by directly targeting AEG‐1 in squamous cell carcinoma of the head and neck
Author(s) -
Zhang Shuiting,
Li Guo,
Liu Chao,
Lu Shanhong,
Jing Qiancheng,
Chen Xiyu,
Zheng Hua,
Ma Huiling,
Zhang Diekuo,
Ren Shuling,
Shen Zhe,
Wang Yunyun,
Lu Zhaoyi,
Huang Donghai,
Tan Pingqing,
Chen Jie,
Zhang Xin,
Qiu Yuanzheng,
Liu Yong
Publication year - 2020
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.14259
Subject(s) - metastasis , angiogenesis , cancer research , biomarker , medicine , microrna , head and neck cancer , oncology , head and neck squamous cell carcinoma , cancer , biology , gene , biochemistry
Metastasis is a critical determinant for the treatment strategy and prognosis in patients with squamous cell carcinoma of the head and neck (SCCHN). However, the mechanisms underlying SCCHN metastasis are poorly understood. Our study sought to determine the key microRNA and their functional mechanisms involved in SCCHN metastasis. For The Cancer Genome Atlas (TCGA) data analysis, quantitative PCR was used to quantify the level of miR‐30e‐5p in SCCHN and its clinical significance was further analyzed. A series of in vitro and in vivo experiments were applied to determine the effects of miR‐30e‐5p and its target AEG‐1 on SCCHN metastasis. A mechanism investigation further revealed that AEG‐1 was implicated in the angiogenesis and metastasis mediated by miR‐30e‐5p. Overall, our study confirms that miR‐30e‐5p is a valuable predictive biomarker and potential therapeutic target in SCCHN metastasis.