Open AccessEpstein‐Barr virus strain variation and cancer
Author(s) -
Kanda Teru,
Yajima Misako,
Ikuta Kazufumi
Publication year - 2019
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.13954
Subject(s) - virus , biology , nasopharyngeal carcinoma , epstein–barr virus , genome , virology , cancer , strain (injury) , dna sequencing , deep sequencing , gene , genetics , medicine , anatomy , radiation therapy
Epstein‐Barr virus ( EBV ) is a human tumor virus and is etiologically linked to various malignancies. Certain EBV ‐associated diseases, such as Burkitt lymphomas and nasopharyngeal carcinomas, are endemic and exhibit biased geographic distribution worldwide. Recent advances in deep sequencing technology enabled high‐throughput sequencing of the EBV genome from clinical samples. Rapid cloning and sequencing of cancer‐derived EBV genomes, followed by reconstitution of infectious virus, have also become possible. These developments have revealed that various EBV strains are differentially distributed throughout the world, and that the behavior of cancer‐derived EBV strains is different from that of the prototype EBV strain of non‐cancerous origin. In this review, we summarize recent progress and future perspectives regarding the association between EBV strain variation and cancer.