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Neddylation has been researched in many different human carcinomas. However, the roles of neural precursor cell expressed, developmentally downregulated 8 ( NEDD 8) in bladder cancer are still unknown. Our study was the first study which systematically investigated the possible functions of  NEDD 8 in bladder cancer ( BC ) progression. We carried out immunohistochemistry to explore associations between the expression of  NEDD 8 in tumor tissues and clinical outcomes of patients.  RT ‐ qPCR  and western blot were used to detect the expressional levels of genes. The biological abilities of cell proliferation, migration and invasion were researched by in vitro and in vivo experiments. Results were as follows: Data from The Cancer Genome Atlas ( TCGA ) database showed that  NEDD 8 was overexpressed in  BC  tissues and was associated with poor patient survival. Results of immunohistochemistry found that  NEDD 8 was significantly associated with poor clinical outcomes of  BC  patients. Suppression of  NEDD 8 could inhibit the proliferation, migration and invasion of tumor cells. Knocking down  NEDD 8 could induce apoptosis and G2 phase arrest of cell cycle progression. In vivo, suppression of  NEDD 8 restricted growth and metastasis of tumors in mice. In conclusion,  NEDD 8 has important roles in regulating the progression of  BC  cells and was associated with poor prognosis of patients; hence, it may become a potential therapeutic target of  BC .

cancer science

Neural precursor cell expressed, developmentally downregulated 8 promotes tumor progression and predicts poor prognosis of patients with bladder cancer