Open AccessThe role of sphingosine‐1‐phosphate in inflammation and cancer progression
Author(s) -
Nagahashi Masayuki,
Abe Manabu,
Sakimura Kenji,
Takabe Kazuaki,
Wakai Toshifumi
Publication year - 2018
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.13802
Subject(s) - inflammation , tumor microenvironment , cancer , sphingosine 1 phosphate , carcinogenesis , angiogenesis , lipid signaling , tumor progression , lymphangiogenesis , cancer research , chemokine , immune system , immunology , sphingosine , biology , medicine , metastasis , receptor
Many inflammatory mediators are involved in the process of carcinogenesis and cancer progression. In addition to cytokines and chemokines, lipid mediators have recently attracted attention as signaling molecules associated with inflammatory diseases. Sphingosine‐1‐phosphate (S1P) is a pleiotropic lipid mediator that regulates cell survival and migration, immune cell recruitment, angiogenesis and lymphangiogenesis. S1P also plays a significant role in inflammation and cancer. The gradation of S1P concentration in the blood, lymph and tissue regulates lymphocyte trafficking, an important component of inflammation. Furthermore, cancer cells produce elevated levels of S1P, contributing to the tumor microenvironment and linking cancer and inflammation. Future technological advances may reveal greater detail about the mechanisms of S1P regulation in the tumor microenvironment and the contribution of S1P to cancer progression. Considering the critical role of S1P in linking inflammation and cancer, it is possible that the S1P signaling pathway could be a novel therapeutic target for cancers with chronic inflammation.