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Dysregulation of the cell cycle is a key indicator of tumors, including lung cancer. Recently, the study of cell cycle inhibitors has made great progress in relation to lung cancer. However, the question of what kinds of patients can use cell cycle inhibitors has plagued us. Therefore, seeking an accurate and convenient marker for the abnormal cell cycle in lung cancer is very important. In the present research, we showed that lnc RNA HOTAIR  is an optimal indicator of cell cycle dysregulation in lung cancer. In the present study, we investigated  HOTAIR ‐specific expression in lung primary tumor samples by analyzing the  TCGA  public database and 67 pairs of patients’ tissues collected from our department. Through the  TCGA  public database  KEGG  analysis,  HOTAIR  correlates with the cell cycle pathway. We identified that  HOTAIR  and its 2 segments,  HOTAIR 3′ and  HOTAIR 5′, promote the cell cycle passing through the restriction point during G1‐S phase by regulating the Rb‐E2F pathway and influence non–small‐cell lung cancer cell proliferation, migration and invasion through epithelial‐mesenchymal transition ( EMT ) and the β‐catenin pathway in vitro and vivo. Finally, we showed that the high expression of  HOTAIR  was associated with resistance to gefitinib through the dysregulated cell cycle. In conclusion,  HOTAIR  could be an ideal indicator of cell cycle dysregulation and guide the use of cell cycle inhibitors.

HOTAIR , a long noncoding RNA , is a marker of abnormal cell cycle regulation in lung cancer