Retracted:  Hispidulin suppresses cell growth and metastasis by targeting   PIM 1  through  JAK 2/ STAT 3 signaling in colorectal cancer | Zendy

Liu Kaili | Zendy; Gao Hui | Zendy; Wang Qiaoyun | Zendy; Wang Longyuan | Zendy; Zhang Bin | Zendy; Han Zhiwu | Zendy; Chen Xuehong | Zendy; Han Mei | Zendy; Gao Mingquan | Zendy

Open Access

Retracted: Hispidulin suppresses cell growth and metastasis by targeting PIM 1 through JAK 2/ STAT 3 signaling in colorectal cancer

Author(s) -

Liu Kaili,

Gao Hui,

Wang Qiaoyun,

Wang Longyuan,

Zhang Bin,

Han Zhiwu,

Chen Xuehong,

Han Mei,

Gao Mingquan

Publication year - 2018

Publication title -

cancer science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.035

H-Index - 141

eISSN - 1349-7006

pISSN - 1347-9032

DOI - 10.1111/cas.13575

Subject(s) - cancer research , colorectal cancer , metastasis , cell growth , oncogene , gene knockdown , downregulation and upregulation , stat , cancer , apoptosis , chemistry , pharmacology , medicine , cell cycle , biochemistry , stat3 , gene

Colorectal cancer ( CRC ) accounts for over 600 000 deaths annually worldwide. The current study aims to evaluate the value of proto‐oncogene PIM 1 as a therapeutic target in CRC and investigate the anticancer activity of hispidulin, a naturally occurring phenolic flavonoid compound, against CRC . Immunohistochemistry analysis showed that PIM 1 was upregulated in CRC tissue. The role of PIM 1 as an oncogene was evidenced by the fact that PIM 1 knockdown inhibits cell growth, induces apoptosis, and suppresses invasion. Our results showed that hispidulin exerts antitumor activity in CRC through inhibiting the expression of PIM 1 . Moreover, our findings revealed that hispidulin downregulated the expression of PIM 1 by inhibiting JAK 2/ STAT 3 signaling by generating reactive oxygen species. Furthermore, our in vivo studies showed that hispidulin can significantly inhibit tumor growth and metastasis in CRC . Collectively, our results provide an experimental basis for trialing hispidulin in CRC treatment. PIM 1 can be considered a potential therapeutic target in CRC .

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