Open AccessExosomes serve as nanoparticles to suppress tumor growth and angiogenesis in gastric cancer by delivering hepatocyte growth factor si RNA
Author(s) -
Zhang Haiyang,
Wang Yi,
Bai Ming,
Wang Junyi,
Zhu Kegan,
Liu Rui,
Ge Shaohua,
Li JiaLu,
Ning Tao,
Deng Ting,
Fan Qian,
Li Hongli,
Sun Wu,
Ying Guoguang,
Ba Yi
Publication year - 2018
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.13488
Subject(s) - microvesicles , hepatocyte growth factor , angiogenesis , rna , cancer research , cancer cell , cancer , growth factor , microbiology and biotechnology , biology , microrna , chemistry , receptor , biochemistry , genetics , gene
Exosomes derived from cells have been found to mediate signal transduction between cells and to act as efficient carriers to deliver drugs and small RNA . Hepatocyte growth factor ( HGF ) is known to promote the growth of both cancer cells and vascular cells, and the HGF ‐ cMET pathway is a potential clinical target. Here, we characterized the inhibitory effect of HGF si RNA on tumor growth and angiogenesis in gastric cancer. In addition, we showed that HGF si RNA packed in exosomes can be transported into cancer cells, where it dramatically downregulates HGF expression. A cell co‐culture model was used to show that exosomes loaded with HGF si RNA suppress proliferation and migration of both cancer cells and vascular cells. Moreover, exosomes were able to transfer HGF si RNA in vivo, decreasing the growth rates of tumors and blood vessels. The results of our study demonstrate that exosomes have potential for use in targeted cancer therapy by delivering si RNA .