English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Exosomes derived from cells have been found to mediate signal transduction between cells and to act as efficient carriers to deliver drugs and small  RNA . Hepatocyte growth factor ( HGF ) is known to promote the growth of both cancer cells and vascular cells, and the  HGF ‐ cMET  pathway is a potential clinical target. Here, we characterized the inhibitory effect of  HGF  si RNA  on tumor growth and angiogenesis in gastric cancer. In addition, we showed that  HGF  si RNA  packed in exosomes can be transported into cancer cells, where it dramatically downregulates  HGF  expression. A cell co‐culture model was used to show that exosomes loaded with  HGF  si RNA  suppress proliferation and migration of both cancer cells and vascular cells. Moreover, exosomes were able to transfer  HGF  si RNA  in vivo, decreasing the growth rates of tumors and blood vessels. The results of our study demonstrate that exosomes have potential for use in targeted cancer therapy by delivering si RNA .

Exosomes serve as nanoparticles to suppress tumor growth and angiogenesis in gastric cancer by delivering hepatocyte growth factor si RNA