English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

The proliferation of prostate cancer cells is controlled by the androgen receptor ( AR ) signaling pathway. However, the function of  AR  target genes has not been fully elucidated. In previous studies, we have identified global  AR  binding sites and  AR  target genes in prostate cancer cells. Here, we focused on Claudin 8 ( CLDN 8), a protein constituting tight junctions in cell membranes. We found one  AR  binding site in the promoter region and two functional androgen‐responsive elements in the sequence. Reporter assay revealed that transcriptional activation of the   CLDN 8  promoter by androgen is dependent on these androgen‐responsive elements. Furthermore,   CLDN 8   mRNA  is induced by androgen time‐dependently and the induction is blocked by  AR  inhibitor, suggesting that  AR  is involved in the transcriptional activation. In addition, our functional analyses by overexpression and knockdown of   CLDN 8   mRNA  indicate that  CLDN 8 promotes prostate cancer cell proliferation and migration. Claudin 8 was overexpressed in prostate cancer clinical samples compared to benign tissues. Furthermore, we found that  CLDN 8 regulates intracellular signal transduction and stabilizes the cytoskeleton. Taken together, these results indicate that  CLDN 8 functions as an  AR  downstream signal to facilitate the progression of prostate cancer. Claudin 8 may be a novel molecular target for prostate cancer therapy.

CLDN 8 , an androgen‐regulated gene, promotes prostate cancer cell proliferation and migration