English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Recent studies have shown that metastasis‐associated lung adenocarcinoma transcript 1 ( MALAT 1) was overexpressed in many human solid cancers, however, its roles in plasma of hepatocellular carcinoma ( HCC ) patients were unclear. The aim of this study was to investigate the significance of plasma  MALAT 1 levels in  HCC  patients. Plasma samples were collected from pre‐operative  HCC , hepatic disease patients, and healthy controls, and tissue samples from  HCC  patients and colorectal cancer patients with liver metastasis. Plasma and tissue  MALAT 1 levels were measured. Plasma  MALAT 1 levels were progressively and significantly higher in  HCC  patients than hepatic disease patients, and higher in hepatic disease patients than healthy controls. The expression of  MALAT 1 in  HCC  tissue was slightly higher than that in paired non‐cancerous liver tissue, but not significant. The expression of  MALAT 1 in the non‐cancerous liver tissue of 20  HCC  patients was significantly higher than that in normal liver tissue of 13 colorectal cancer patients. In contrast, plasma  MALAT 1 levels were significantly low in  HCC  patients with hepatitis B infection, and significantly high in patients with liver damage B or liver cirrhosis. In a receiver–operator curve analysis of  HCC  and hepatic disease patients, the cut‐off value of plasma  MALAT 1 was 1.60 and the area under the curve was 0.66. Plasma  MALAT 1 levels were not correlated with α‐fetoprotein or protein induced by vitamin K absence  II , whereas sensitivity and specificity for the detection of  HCC  with the combination of  MALAT 1, α‐fetoprotein, and protein induced by vitamin K absence  II  were 88.6% and 75%, respectively. In conclusion, the plasma  MALAT 1 level is associated with liver damage, and has clinical utility for predicting development of  HCC .

cancer science

Plasma level of metastasis‐associated lung adenocarcinoma transcript 1 is associated with liver damage and predicts development of hepatocellular carcinoma