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The International Neuroblastoma Pathology Classification ( INPC ) has a prognostic impact that distinguishes two categories of neuroblastoma: favorable histology ( FH ) and unfavorable histology ( UH ). We analyzed 92 cases of neuroblastoma with the  INPC  evaluation and genomic grouping to investigate the correlation between the  INPC  and genomic signature, together with their prognostic significance. The correlation of  UH  tumor and partial gains and/or losses ( GGP ), as well as the correlation of  FH  tumor and whole gains and/or losses ( GGW ), was statistically significant. Both  UH  and  GGP  were late‐onset (median age at diagnosis was 36 and 48 months, respectively) and had poor prognosis (overall survival rate [ OS ], 43.1% and 42.4%, respectively). In contrast, both  FH  and  GGW  were early‐onset (median age at diagnosis, 4 and 9.5 months, respectively) and had favorable prognosis ( OS , 88.6% and 87.1%, respectively). Unfavorable histology and  GGP  had significantly inferior  OS  compared to  FH  and  GGW . Overall survival was not significantly different among the genomic groups in  FH ; however, it was inferior in  UH  with  GGP . In  UH  with a single copy   MYCN  , genomic subgroups  GGP 2s (both 1p and 11q losses) and  GGP 3s (partial 11q loss but not 1p loss) indicated significantly poor prognosis compared to  GGP 4s (no partial 1p and 11q loss). As  INPC  and   MYCN   amplification were found to be the most powerful prognostic biological factors, they should be included with genomic grouping as treatment stratification for patients with  UH  and single copy of   MYCN  .

Correlation between the International Neuroblastoma Pathology Classification and genomic signature in neuroblastoma