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The SMARCE1 (SWI / SNF‐related, matrix‐associated, and actin‐dependent regulator of chromatin, subfamily e, member 1) encodes BAF57 protein. Previously, we reported that  BAF 57 is a predictive marker of endometrial carcinoma. In this study, we investigated  BAF 57 expression in ovarian cancer cell lines and their sensitivities to cisplatin, doxorubicin, paclitaxel, and 5‐fluorouracil.  BAF 57 expression was strongly correlated with sensitivities to cisplatin, doxorubicin, and 5‐fluorouracil in 10 ovarian cancer cell lines. Paclitaxel sensitivity was also correlated with  BAF 57 expression, but without significance. In A2780 ovarian cancer cells, knockdown of  BAF 57 using specific si RNA  increased cell cycle arrest at G 1  phase and the sensitivities to these anticancer agents.  cDNA  microarray analysis of A2780 cells transfected with  BAF 57 si RNA  showed that 134 genes were positively regulated by  BAF 57, including  ATP ‐binding cassette, sub‐family G (  WHITE  ), member 2 (  ABCG 2 ) encoding breast cancer resistance protein ( BCRP ). We confirmed that knockdown of  BAF 57 decreased  BCRP  expression in ovarian cancer cells by Western blot analysis, and that   ABCG 2  gene expression might be regulated transcriptionally. These results suggested that  BAF 57 is involved in ovarian cancer cell growth and sensitivity to anticancer agents, and that  BAF 57 may be a target for ovarian cancer therapy.

Expression of BAF57 in ovarian cancer cells and drug sensitivity