Open AccessP16 INK4A as a surrogate biomarker for human papillomavirus‐associated oropharyngeal carcinoma: Consideration of some aspects
Author(s) -
Wang Hongzhi,
Sun Rui,
Lin Hui,
Hu Weihan
Publication year - 2013
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.12287
Subject(s) - biomarker , surrogate endpoint , human papillomavirus , oncology , medicine , pathological , cancer research , pathology , biology , genetics
Human papillomavirus ( HPV )‐associated oropharyngeal squamous cell carcinomas ( OPSCC s) frequently show different clinical and pathological features, which tend to be younger age, better performance status, less tobacco and alcohol consumption, more poorly differentiated histopathology, but usually with better treatment response and prognosis compared with HPV ‐negative OPSCC s. In tumor tissue, HPV infection is closely correlated with p16 INK4A expression, which has been suggested to be a surrogate biomarker of HPV infection. However, there is diversity of sensitivity and specificity about p16 INK4A in surrogate detection of HPV status. Herein, we summarize the current knowledge and note some aspects for consideration concerning p16 INK4A as a surrogate biomarker for HPV ‐associated OPSCC .